Реакция вазоактивного интестинального полипептида - VIP - на висцеральную травму

Abstract

Вазоактивный интестинальный полипептид –VIP, секретируемый больших дозах при висцеральной травме, действует как вазоконстриктор и наряду с другими биологически активными веществами помогает организму компенсировать тяжёлые гемодинамические сдвиги - гиповолемию и гипотензию.

It is known that VIP is a neurotransmitter. In our case, with visceral trauma, its secretion from neurons and axons of nerve endings occurs under the influence of strong nociceptive impulses from the focus of trauma and the stimulation of the sympathoadrenal system. Depending on the concentration, it can act on the blood vessels in two different directions. In large doses, it manifests itself as a vasoconstrictor and along with other similar substances (renin-angiotensin-aldosterone system) helps the body compensate for hemodynamic changes - hypovolemia and hypotension - characteristic of visceral trauma. In one case, the organism survives. And in another case - all the efforts of the homeostatic system of adaptation are vain and the organism dies.